We performed a review of literature (MEDLINE and EMBASE database), without limited date or publication restrictions.Īngelman Syndrome Cataplexy Narcolepsy Niemann-Pick type C Disease Norrie Disease Prader-Willi Syndrome.Ĭopyright © 2019 Elsevier B.V. Narcolepsy type 2 is defined as narcolepsy without cataplexy. In this review, we described few conditions of cataplexy not related to narcolepsy. Therefore, it is essential disconnecting cataplexy from narcolepsy especially in pediatric population and after use of a few medications. Yet, the most prevalent causes of cataplexy without narcolepsy are rare genetic diseases which explains why cataplexy is classically linked to narcolepsy. In addition, cataplexy can be a side effect of several drugs (eg, lamotrigine, clozapine, and gamma-hydroxybutyrate). Narcolepsy isn’t very common about 1 in every 2,000 people are estimated to have it. There are two types of narcolepsy, type 1 (narcolepsy and cataplexy) and type 2 (narcolepsy without cataplexy). Cataplexy is when the leg, arm or face muscles suddenly become weak. Less is known about type 2 narcolepsy, some researchers believe it could encompass a variety of different. People with narcolepsy easily go into rapid eye movement (REM) sleep, a sleep stage in which the eyes may appear to be moving and dreams typically occur. Narcolepsy with cataplexy Narcolepsy without cataplexy. Type 2 Narcolepsy (narcolepsy without cataplexy). Larger studies with consistent clinical phenotyping should be the focus of future investigations. Other causes of cataplexy include Niemann-Pick type C Disease, Angelman Syndrome, Norrie Disease, Prader-Willi Syndrome. Narcolepsy is a chronic brain disorder that causes severe daytime sleepiness. Most neuroimaging studies to date have been conducted in small samples, while narcolepsy type 2 (or narcolepsy without cataplexy) and idiopathic hypersomnia remain relatively understudied. Cataplexy is a transient loss of muscle tone that can be triggered by emotions such as laughter, excitement or fear.
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